- 下列哪一個藥物長期使用可能會造成beta-receptor的up-regulation?
(A) Propanolol
(B) Clonidine
(C) Physostigmine
(D) 以上皆非
- 副交感神經傳遞物質能夠經由哪個受體的活化來抑制心跳速率?
(A) Muscarinic M3
(B) Muscarinic M1
(C) Muscarinic M2
(D) 以上皆非
(A) Alpha 1 receptor
(B) Beta 2 receptor
(C) Alpha 2 receptor
(D) Beta 1 receptor
- 以下哪個胺基酸是Norepinephrine的前驅物?
(A) Glutamine
(B) Glycine
(C) Choline
(D) Tyrosine
- 以下有關Norepinephrine引起的生理反應何者為非?
(A) 增加心跳速率
(B) 造成支氣管擴張
(C) 使血管收縮並增加血壓
(D) 作用到突觸前alpha-2受體進而減少Norepinephrine的釋放
(A) angina
(B) asthma
(C) arrythmia
(D) hypertension
- 以下有關alpha-1 receptor agonist作用的敘述何者為非?
(A) 可升高血壓
(B) 可用於治療鼻充血
(C) 具有散瞳作用
(D) 可增加心跳速率
- beta receptor antagonist不適合用於治療和者疾病?
(A) hypertension
(B) angina
(C) asthma
(D) glaucoma
(A) 有機磷殺蟲劑中毒
(B) amphetamine中毒
(C) nicotine中毒
(D) cocaine中毒
- Which of the following is not correct in feature of receptor?
(A) It may require more than one drug molecule to bind to a receptor and elicit a responder.
(B) Specificity of drug binding to receptors is not absolute.
(C)The KD of drug binding to receptors is generally in the range of 1 to 100 μmol/L
(D) By acting on receptors, drug can enhance, diminish, or block generation or transmission of signal.
- Hormone signaling can occur by:
(A) Tyrosine Phosphorylation
(B) Receptor association with G-protein
(C) Formation of second messenger, such as cAMP
(D) All are correct.
- Dose-response cuves are used for drug evaluation in the animal laboratory and in the clinical Quantal dose-response curves are often:
(A) Used for determining the maximal efficacy of a drug.
(B) Used for determing the therapeutic index of a drug.
(C) Used for evaluation of the toxicity of a drug
(D) Used for determining the potency of a drug
- Full activation of the sympathetic nervous system, as in maximal exercise, can produce all of the following response EXCEPT:
(A) Mydriasis
(B) Increased intestinal motility
(C) Bronchial relaxation
(D) Tachycardia (increased heart rate)
- Nicotinic receptors sites include all of the following EXCEPT:
(A) Skeletal muscles
(B) Bronchial smooth muscles
(C) Parasympathetic ganglia
(D) Symphathetic ganglia
- Stimulation of presynaptic alpha-2 adrenergic recedptor on sympathetic neurons causes the following:
(A) Stimulation of NE release
(B) Stimulation of ACh release
(C) Inhibition of NE release
(D) Inhibition of ACh release
- Activation of the parasympathetic nervous system results in which of the following response?
(A) Renin secretion
(B) An increase in heart rate
(C) Vasoconstriction
(D) Bronchoconstriction
- A 54-yo man complains of excessive tiredness and weakness upon exertion. Myasthenia gravis is suspected. Which of the following drugs would be most suitable for the chronic treatment of this disease?
(A) Atropine
(B) Physostigmine
(C) Pyridostigmine
(D) Pralidoxime
- A patient requires mild cholinomimetic stimulation following surgery. Physostigmine and Bethenachol in small doses have similar effects on all of the following EXCEPT
(A) Sweat glands
(B) Salivary glands
(C) Ureteral tone
(D) Neuromuscular junction between skeletal muscles
- beta-2 selective stimulants are often effective in:
(A) Delayed or insufficiently strong labor
(B) Asthma
(C) Ischemic ulcers of the skin
(D) Angina